anemodeanin A, oleanolic acid 3-O-alpha-rhamnopyranosyl(1-2)-beta-glucopyranosyl(1-2)-alpha-arabinopyranoside
| Name | Raddeanin A | ||
| PubChem CID | 174742 | ||
| Molecular Weight | 897.1g/mol | ||
| Synonyms |
anemodeanin A, oleanolic acid 3-O-alpha-rhamnopyranosyl(1-2)-beta-glucopyranosyl(1-2)-alpha-arabinopyranoside |
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| Formula | C₄₇H₇₆O₁₆ | ||
| SMILES | CC1C(C(C(C(O1)OC2C(C(C(OC2OC3C(C(COC3OC4CCC5(C(C4(C)C)CCC6(C5CC=C7C6(CCC8(C7CC(CC8)(C)C)C(=O)O)C)C)C)O)O)CO)O)O)O)O)O | ||
| InChI | 1S/C47H76O16/c1-22-30(50)33(53)35(55)38(59-22)62-37-34(54)32(52)26(20-48)60-40(37)63-36-31(51)25(49)21-58-39(36)61-29-12-13-44(6)27(43(29,4)5)11-14-46(8)28(44)10-9-23-24-19-42(2,3)15-17-47(24,41(56)57)18-16-45(23,46)7/h9,22,24-40,48-55H,10-21H2,1-8H3,(H,56,57)/t22-,24-,25-,26+,27-,28+,29-,30-,31-,32+,33+,34-,35+,36+,37+,38-,39-,40-,44-,45+,46+,47-/m0/s1 | ||
| InChIKey | VQQGPFFHGWNIGX-PPCHTBMASA-N | ||
| CAS Number | 89412-79-3 | ||
| ChEBI ID | CHEBI:228904 | ||
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | ZhuJieXiangFu | ||
| Use Part | Anemone raddeana Regel | ||
| Habitat | HeiLongJiang, JiLin, LiaoNing, ShanDong, HeBei, ShanXi, JiLin | ||
| Flavor | Pungent; Slightly Sweet; Slightly Bitter | ||
| Meridian Tropism | Spleen; Liver; Three End | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Ranunculales
-->Family: Ranunculaceae
-->Genus: Anemone
-->Species: Anemone Raddeana
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| Pair Name | Raddeanin A, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G0/G1 phase | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | BIRC5 | hsa332 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | QGY-7703 | Papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_6715 |
| Result | All these consequences reflect RA plays an important role in enhancing the therapeutic effect of cisplatin in HCC. This finding may guide for the drug usage of cisplatin in clinic practice. | |||
