anemodeanin A, oleanolic acid 3-O-alpha-rhamnopyranosyl(1-2)-beta-glucopyranosyl(1-2)-alpha-arabinopyranoside
| Name | Raddeanin A | ||
| PubChem CID | 174742 | ||
| Molecular Weight | 897.1g/mol | ||
| Synonyms |
anemodeanin A, oleanolic acid 3-O-alpha-rhamnopyranosyl(1-2)-beta-glucopyranosyl(1-2)-alpha-arabinopyranoside |
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| Formula | C₄₇H₇₆O₁₆ | ||
| SMILES | CC1C(C(C(C(O1)OC2C(C(C(OC2OC3C(C(COC3OC4CCC5(C(C4(C)C)CCC6(C5CC=C7C6(CCC8(C7CC(CC8)(C)C)C(=O)O)C)C)C)O)O)CO)O)O)O)O)O | ||
| InChI | 1S/C47H76O16/c1-22-30(50)33(53)35(55)38(59-22)62-37-34(54)32(52)26(20-48)60-40(37)63-36-31(51)25(49)21-58-39(36)61-29-12-13-44(6)27(43(29,4)5)11-14-46(8)28(44)10-9-23-24-19-42(2,3)15-17-47(24,41(56)57)18-16-45(23,46)7/h9,22,24-40,48-55H,10-21H2,1-8H3,(H,56,57)/t22-,24-,25-,26+,27-,28+,29-,30-,31-,32+,33+,34-,35+,36+,37+,38-,39-,40-,44-,45+,46+,47-/m0/s1 | ||
| InChIKey | VQQGPFFHGWNIGX-PPCHTBMASA-N | ||
| CAS Number | 89412-79-3 | ||
| ChEBI ID | CHEBI:228904 | ||
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | ZhuJieXiangFu | ||
| Use Part | Anemone raddeana Regel | ||
| Habitat | HeiLongJiang, JiLin, LiaoNing, ShanDong, HeBei, ShanXi, JiLin | ||
| Flavor | Pungent; Slightly Sweet; Slightly Bitter | ||
| Meridian Tropism | Spleen; Liver; Three End | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Ranunculales
-->Family: Ranunculaceae
-->Genus: Anemone
-->Species: Anemone Raddeana
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| Pair Name | Raddeanin A, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G0/G1 phase | |||
| Gene Regulation | Up-regulation | Expression | TP53 | hsa7157 |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Down-regulation | Expression | BIRC5 | hsa332 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| In Vitro Model | QGY-7703 | Papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_6715 |
| Result | Synergy of Raddeanin A and cisplatin induced therapeutic effect enhancement in human hepatocellular carcinoma | |||
